In NY week before Hallowean. Read informative article in New Yorker on background to the opioid crisis in US. Shocking.
It’s hit the news stands here. See links below.
Could apomorphine help?
Professor Andrew Lees, UCL, suggests it might.
He writes: “The mesolimbic dopamine pathway is believed to be involved in the neurobiology of addiction. Apomorphine is a powerful D2 and D3 agonist which reduces craving in alcoholics and in opioid and psychostimulant addicts.
In Parkinson’s disease when administered by continuous subcutaneous infusion it can reduce dyskinesias in l-dopa treated patients. This is believed to be due to a reduction in dorsal striatal sensitisation. Ventral striatal de-sensitisation with apomorphine seems a more scientifically viable approach to the treatment of opioid addiction than either methadone or buprenorphine and justifies a controlled trial in which volunteers receive either apomorphine or saline infusion continuously for 5 days and are then followed up for a year.”
Links for more info’ on the Opioid crisis.
The New Statesman